ARTICLE DOI: 10.31480/2330-4871/018


Research leads clinical practice

Yuguang Huang , MD

Department of Anesthesiology, Peking Union Medical College Hospital

*Corresponding author: Yuguang Huang, MD, Professor and Chair. Department of Anesthesiology, Peking Union Medical College Hospital, E-mail:

Editor: Renyu Liu, MD, PhD, Director of Preoperative Medicine, Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania Email:

Received: March 04, 2015 | Accepted: March 06, 2015 | Published: March 10, 2015

Citation: Huang Y. Research leads clinical practices. Transl Perioper & Pain Med 2015, 2(1): 9.

The recent discussion for the perspective of translational medicine using WeChat social media hosted by the Journal of the "Translational Perioeprative and Pain Medicine" is very successful for exchanging ideas between scientists and clinicians [1]. Medicine is an art in itself. Since there are many unknown and uncontrollable factors, the quality management in medicine can only be called "Quality Assurance", not the same as the "Quality Control" used in the industry for the quality management. The purpose of medical research is to transform the medicine into science whenever it is possible.

Emphasis on translational medicine is the requirement and inevitable for the current era. The funding spend in basic science is skyrocketing here in China and abroad, however, as a matter of fact, the clinical return from such research spending is unsatisfactory. The essence of medicine is to save lives and cure diseases, and the ultimate goal of research is to improve the clinical practice; therefore, "Research Leads Clinical Practice" should become a common consensus.

Patient-controlled analgesia (PCA) in pain management is one of the great examples of translational medicine. Traditionally, treatment of postoperative pain in patients was achieved very poorly by intermittent intramuscular injection of medication. With the advances in pharmacology, especially with the better understanding of therapeutic window and pd/pk models, individualized pain management becomes possible and practical.

I studied in University of Utah in 1991. Immediately after returning home in 1993, I advocated and promoted the PCA technology in China. With the joint efforts from our colleagues, we advanced individualized clinical pain management in China significantly[2]. The development of oral transmucosal fentanyl citrate is another great example of pharmacology and physiological research promoting clinical advancement[3,4]. Today, the many clinical issues and dilemma remain needing more basic science research. These clinical problems raise more expectations and requirements for basic science research.

Disclosure of Funding



  1. Hu L, Zhang J, Tu W, Liu R, Zhang L (2015) Perspectives of Translational Medicine. Transl Periop & Pain Med 2: 12-18.
  2. Guo X, Li Y, Ye T, Ren H, Huang Y, et al. (2003) Clinical study of patient-controlled epidural analgesia with tetracaine hydrochloride after pulmonary lobectomy. Chin Med Sci J 18: 54-58.
  3. Ashburn MA, Fine PG, Stanley TH (1989) Oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: a case report. Anesthesiology 71: 615-617.
  4. Bhatnagar S, Devi S, Vinod N, Jain P, Durgaprasad G, et al. (2014) Safety and efficacy of oral transmucosal fentanyl citrate compared to morphine sulphate immediate release tablet in management of breakthrough cancer pain. Indian J Palliat Care 20: 182-187.